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–+ servings
A serving of shepherd's pie with a golden, cheesy mashed potato topping and seasoned ground meat filling, reminiscent of a Sloppy Joe Casserole, garnished with chopped parsley on a ceramic plate with a fork and knife.

Sloppy Joe Casserole

Mandy Applegate
I make Sloppy Joe Casserole when I want all the tangy, savory flavors of traditional sloppy joes in one easy pan. The ground beef mixture gets topped with fluffy Bisquick biscuit batter and melted cheddar, then bakes until golden and bubbly. Unlike regular sloppy joes, there's no sauce dripping down your hands or soggy buns falling apart. It's perfect for weeknight family dinners, potlucks, game day parties, and meal prep because kids love the familiar taste and it's crowd-friendly.
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Prep Time 15 minutes
Cook Time 30 minutes
Total Time 45 minutes
Course Casserole, Dinner, Main Course
Cuisine American
Servings 6
Calories 425 kcal

Ingredients
 
 

  • 1 pound lean ground beef
  • 1 medium onion diced
  • 1 cup ketchup
  • 1 tablespoon yellow mustard
  • 2 cups Bisquick mix
  • 1 cup milk
  • 1 cup shredded cheddar cheese
  • Fresh parsley chopped (for garnish)

Instructions
 

  • Preheat the oven to 375°F (190°C) and lightly spray a baking dish with nonstick cooking spray.
  • In a skillet over medium heat, cook the ground beef and diced onion until the beef is browned. Drain any excess fat.
    1 pound lean ground beef, 1 medium onion
  • Stir in the ketchup and mustard, then let the mixture simmer for about 5 minutes.
    1 cup ketchup, 1 tablespoon yellow mustard
  • In a mixing bowl, combine the Bisquick mix and milk until smooth to form the biscuit batter.
    2 cups Bisquick mix, 1 cup milk
  • Spread the beef mixture evenly in the prepared baking dish. Pour the biscuit batter over the top, then sprinkle with shredded cheddar cheese.
    1 cup shredded cheddar cheese
  • Bake for 25 to 30 minutes, or until the top is golden brown and the casserole is bubbly.
  • Garnish with fresh parsley before serving.
    Fresh parsley

Video

Notes

I've got a few tips to help you make the best homemade sloppy joe casserole.
Drain the meat well: After browning the ground beef, make sure to drain off any excess fat so the casserole doesn't end up greasy. Lean ground beef works best for keeping the filling from getting oily. Ground turkey works well, too.
Add depth with spices: Stir in 1 teaspoon paprika, 1 teaspoon garlic powder, and 1/4 teaspoon red pepper flakes to the beef mixture when you add the ketchup and mustard for extra depth, a slight smokiness, and a little heat that cuts through the richness of the cheese.
Customize the filling: Mix in brown sugar for a hint of sweetness to balance the tanginess, swap half the ketchup with tomato sauce for a more savory base, add a little vinegar for extra tang, or stir in green bell pepper with the beef and onion to bulk up the filling with vegetables.
Let it rest before serving: Give the casserole about 5 minutes to cool after it comes out of the oven. This helps the layers set up so you can scoop out neat portions instead of having everything slide around on the plate.
Customize the cheese: You can swap the cheddar for Monterey Jack, Colby, or a Mexican cheese blend if you want a different flavor. Just make sure to use a cheese that melts well so you get that gooey, bubbly top.
Store properly: Refrigerate the covered dish for 3-4 days, or flash-freeze portions, then freeze in freezer containers for up to 3 months to keep them from sticking together and so you can grab just what you need later. Thaw overnight in the fridge and warm in the oven or microwave.

Nutrition

Calories: 425kcalCarbohydrates: 40gProtein: 26gFat: 18gSaturated Fat: 8gPolyunsaturated Fat: 1gMonounsaturated Fat: 7gTrans Fat: 0.3gCholesterol: 71mgSodium: 1090mgPotassium: 545mgFiber: 1gSugar: 16gVitamin A: 464IUVitamin C: 3mgCalcium: 273mgIron: 3mg
Keyword Sloppy Joe Casserole
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